People

Patricia Martins, Ph.D.

Postdoctoral Fellows

Research Interests

My research interests include the Blood-Brain barrier and other lipidic barriers permeation, drug delivery systems and their interaction with biomembranes, the kinetics and thermodynamics of the interaction of drugs and drug carriers with lipidic membranes and the understanding of the mechanisms underlying loading and release of functional molecules into and from their carriers.

Selected Publications

Thermo-Responsive Pegylated Bubble Liposome Nanovectors for Efficient siRNA Delivery via Endosomal Escape

K. Alamoudi, P. A. T. Martins, H. Omar and N. M. Khashab

Nanomedicine, accepted, 2017

Self-Assembled Lipoprotein Based Gold Nanoparticles for Detection and Photothermal Disaggregation of beta-Amyloid Aggregates

P. A. T. Martins, S. Alsaiari, K. Julfakyan, Z. Nie, Z. and N. M. Khashab

Chemical Communications 2017, DOI: 10.1039/C6CC09085K

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

H. Omar, J. G. Croissant, K. Alamoudi, S. Alsaiari, I. Alradwan, M. A. Majrashi, D. H. Anjum, P. Martins, B. Moosa, A. Almalik and N. M. Khashab

Journal of Controlled Release 2016, DOI: 10.1016/j.jconrel.2016.11.032

Kinetics of the Interaction of Amphiphiles with Lipid Bilayers using ITC, in "Biocalorimetry: Foundations and Contemporary Approaches"

P. A. T. Martins, A. Velazquez-Campoy and M. J. Moreno

Ed. Margarida Bastos. Florida, US: CRC Press, 2016, ISBN: 978-1-4822-4665-0

Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: mechanisms of action and clinical implications in anti-bacterial prophylaxis

A. Inácio, N. Domingues, A. Nunes, P. Martins, M. Moreno, L. Estronca, R. Fernandes, A. Moreno, M. J. Borrego, J. Gomes, W. Vaz and O. Vieira

Journal of Antimicrobial Chemotherapy, 2015, DOI: 10.1093/jac/dkv405

Interaction of bile salts with model membranes mimicking the gastrointestinal epithelium: A study by isothermal titration calorimetry

F. M. Coreta-Gomes, P. A. T. Martins, A. Velazquez-Campoy, W. L. C. Vaz, C. F. G. Geraldes and M. J. Moreno 

Langmuir 2015, DOI: 10.1021/acs.langmuir/5b01810

Kinetics and thermodynamics of Chlorpromazine interaction with lipid bilayers: effect of charge and cholesterol

P. T. Martins, A. Velazquez-Campoy, W. L. C. Vaz, R. M. S. Cardoso, J. Valerio and M. J. Moreno

Journal of the American Chemical Society 2012, DOI: 10.1021/ja209917q

Chain-length dependence of insertion, desorption and translocation of a homologous series of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled aliphatic amines in membranes

R. M. S. Cardoso, P. A. T. Martins, F. Gomes, S. Doktorovova, W. L. C. Vaz and M. J. Moreno

Journal of Physical Chemistry B, 2011, DOI: 10.1021/jp203429s

Binding of phospholipids to β-lactoglobulin and their transfer to lipid bilayers

P. A. T. Martins, F. Gomes, W. L. C. Vaz and M. J. Moreno

Biochimica et Biophysica Acta - Biomembranes, 2008, DOI: 10.1016/j.bbamem.2008.02.011

Education

​​​2008-2013: Ph.D., Biological Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

2000-2005: B.Sc. (Pre-Bologna), Biochemistry, Faculty of Sciences, University of Lisbon, Lisbon, Portugal​

Professional Profile

​​​​Present: Postdoctoral Fellow, Interfacial Lab, KAUST, Thuwal, Saudi Arabia


2015 - 2017: Postdoctoral Fellow, Smart Hybrid Materials group, KAUST, Thuwal, Saudi Arabia


2014: Postdoctoral fellow, 3B’s group, University of Minho, Braga, Portugal


2013: Graduate research assistant, QOPNA group, University of Aveiro, Aveiro, Portugal


2009-2011: PhD visiting student, BIFI, University of Zaragoza, Zaragoza, Spain


2008-2013: PhD student, Biological Chemistry group, University of Coimbra, Coimbra, Portugal


2007: Graduate research assistant, Biological Chemistry group, University of Coimbra, Coimbra, Portugal​

KAUST Affiliations

​​Water Desalination and Reuse Center (WDRC)


Division of Biological and Environmental Sciences and Engineering (BESE)​​​