Patricia Martins, Ph.D.

Postdoctoral Fellows

Alumni

Research Interest

My research interests include the Blood-Brain barrier and other lipidic barriers permeation, drug delivery systems and their interaction with biomembranes, the kinetics and thermodynamics of the interaction of drugs and drug carriers with lipidic membranes and the understanding of the mechanisms underlying loading and release of functional molecules into and from their carriers.

Selected Publications

  • Thermo-Responsive Pegylated Bubble Liposome Nanovectors for Efficient siRNA Delivery via Endosomal Escape
    K. Alamoudi, P. A. T. Martins, H. Omar and N. M. Khashab
    Nanomedicine, accepted, 2017
  • Self-Assembled Lipoprotein Based Gold Nanoparticles for Detection and Photothermal Disaggregation of beta-Amyloid Aggregates
    P. A. T. Martins, S. Alsaiari, K. Julfakyan, Z. Nie, Z. and N. M. Khashab
    Chemical Communications 2017, DOI: 10.1039/C6CC09085K
  • Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery
    H. Omar, J. G. Croissant, K. Alamoudi, S. Alsaiari, I. Alradwan, M. A. Majrashi, D. H. Anjum, P. Martins, B. Moosa, A. Almalik and N. M. Khashab
    Journal of Controlled Release 2016, DOI: 10.1016/j.jconrel.2016.11.032
  • Kinetics of the Interaction of Amphiphiles with Lipid Bilayers using ITC, in "Biocalorimetry: Foundations and Contemporary Approaches"
    P. A. T. Martins, A. Velazquez-Campoy and M. J. Moreno
    Ed. Margarida Bastos. Florida, US: CRC Press, 2016, ISBN: 978-1-4822-4665-0
  • Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: mechanisms of action and clinical implications in anti-bacterial prophylaxis
    A. Inácio, N. Domingues, A. Nunes, P. Martins, M. Moreno, L. Estronca, R. Fernandes, A. Moreno, M. J. Borrego, J. Gomes, W. Vaz and O. Vieira
    Journal of Antimicrobial Chemotherapy, 2015, DOI: 10.1093/jac/dkv405
  • Interaction of bile salts with model membranes mimicking the gastrointestinal epithelium: A study by isothermal titration calorimetry
    F. M. Coreta-Gomes, P. A. T. Martins, A. Velazquez-Campoy, W. L. C. Vaz, C. F. G. Geraldes and M. J. Moreno
    Langmuir 2015, DOI: 10.1021/acs.langmuir/5b01810
  • Kinetics and thermodynamics of Chlorpromazine interaction with lipid bilayers: effect of charge and cholesterol
    P. T. Martins, A. Velazquez-Campoy, W. L. C. Vaz, R. M. S. Cardoso, J. Valerio and M. J. Moreno
    Journal of the American Chemical Society 2012, DOI: 10.1021/ja209917q
  • Chain-length dependence of insertion, desorption and translocation of a homologous series of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled aliphatic amines in membranes
    R. M. S. Cardoso, P. A. T. Martins, F. Gomes, S. Doktorovova, W. L. C. Vaz and M. J. Moreno
    Journal of Physical Chemistry B, 2011, DOI: 10.1021/jp203429s
  • Binding of phospholipids to β-lactoglobulin and their transfer to lipid bilayers
    P. A. T. Martins, F. Gomes, W. L. C. Vaz and M. J. Moreno
    Biochimica et Biophysica Acta - Biomembranes, 2008, DOI: 10.1016/j.bbamem.2008.02.011

Education

  • 2008-2013: Ph.D., Biological Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal
  • 2000-2005: B.Sc. (Pre-Bologna), Biochemistry, Faculty of Sciences, University of Lisbon, Lisbon, Portugal

Professional Profile

  • Present: Postdoctoral Fellow, Interfacial Lab, KAUST, Thuwal, Saudi Arabia

  • 2015 - 2017: Postdoctoral Fellow, Smart Hybrid Materials group, KAUST, Thuwal, Saudi Arabia

  • 2014: Postdoctoral fellow, 3B’s group, University of Minho, Braga, Portugal

  • 2013: Graduate research assistant, QOPNA group, University of Aveiro, Aveiro, Portugal

  • 2009-2011: PhD visiting student, BIFI, University of Zaragoza, Zaragoza, Spain

  • 2008-2013: PhD student, Biological Chemistry group, University of Coimbra, Coimbra, Portugal

  • 2007: Graduate research assistant, Biological Chemistry group, University of Coimbra, Coimbra, Portugal

KAUST Affiliations

  • Water Desalination and Reuse Center (WDRC)
  • Division of Biological and Environmental Sciences and Engineering (BESE)